Abstract: To enhance core courses in fundamental disciplines and tackle their associated challenges, this study addresses key issues in talent cultivation through targeted interventions. By integrating information technologies (e.g., Xiaoya platgorm, quantum computing software, and MOOCs), virtual simulations, and practical tools, we implement teaching innovations centered on four key integrations: (1) curriculum-based ideological and political education, (2) scientific frontiers with experimental practice, (3) comparative (Compare & Contrast) pedagogy, and (4) problem-driven instruction. These approaches aim to establish a high-quality “Principles of General Chemistry” curriculum system characterized by warmth, depth, and breadth. As the inaugural professional compulsory course for chemistry majors, this curriculum serves as a foundational knowledge platform. Adopting a student-centered approach, it facilitates freshmen's transition from secondary to tertiary education while strengthening their chemical analytical skills, fostering scientific thinking, improving scientific literacy, and cultivating proper worldviews and values. The ultimate objective is to elevate chemistry education quality across four dimensions: professional foundation, scientific thinking, innovation awareness, and societal responsibility (termed the “four integrations, three perspectives, four dimensions” framework).

Key words: Four integrations, three perspectives and four dimensions, Teaching innovation, Principles of general chemistry, Talent cultivation