EDTA滴定法测药物制剂中的ZnO：定量分析在实践中的应用

doi:10.3866/PKU.DXHX202111067

Abstract

Abstract:

Zinc oxide is a usual additive in food, cosmetics, and pharmaceuticals. In this experiment, ZnO content in prickly heat powder and skin ointment was determined by complexometric titration using ethylenediaminetetraacetic acid (EDTA) as the titrant. With real-life pharmaceuticals as experimental materials, it could stimulate the students' interests in learning the applications of complexometric titrations in quality control. By comparing the experimental results with label information, the students could better understand and master the principle of complexometric titration, experimental operation and analysis of experimental results.

Key words: Complexometric titration, Zinc oxide, Analytical chemistry experiment

Hongwei Zhao, Jiameng Huai, Ze Wang, Xia Chen. Complexometric Titration for the Determination of Zno in Pharmaceutical Preparations: Application of Quantitative Chemical Analysis in Practice[J].University Chemistry, 2022, 37(12): 2111067.

编号	V_Zn²⁺/mL	V_EDTA/mL	C_EDTA/(mol?L^?1)	${\bar C}$_EDTA/(mol?L^?1)	RSD/%
1	25.00	24.60	0.01040	0.01040	0
2	25.00	24.55	0.01040
3	25.00	24.60	0.01040

样品	m_s/g	编号	V_Zn²⁺/mL	V_EDTA/mL	ZnO%	ZnO% (平均值)	RSD/%
痱子粉	3.7502	1	25.00	22.07	0.4958	0.4965	0.14
		2		22.11	0.4967
		3		22.13	0.4970
软膏	0.12509	1	25.00	22.26	15.00	14.97	0.14
		2		22.21	14.96
		3		22.20	14.94

样品	测得值/(mg?g^?1)	标签值/(mg?g^?1)	E_r/%
痱子粉	4.96	5	?0.69
软膏	149.7	150	?0.20

m_ZnO/(mg?g^?1)	标签值/(mg?g^?1)	RSD/%	E_r/%
4.9571	5	0.22	?0.85
4.9624		0.13	?0.75
4.9517		0.11	?0.96
4.9650		0.38	?0.69
4.9704		0.32	?0.59
4.9571		0.25	?0.85
4.9491		0.50	?0.98
4.9544		0.48	?0.91
4.9784		0.10	?0.43
5.0024		0.33	0.05

m_ZnO/(mg?g^?1)	标签值/(mg?g^?1)	RSD/%	E_r/%
149.09	150	0.41	?0.53
149.25		0.46	?0.43
149.33		0.48	?0.37
150.13		0.22	0.16
149.41		0.25	?0.32

Complexometric Titration for the Determination of Zno in Pharmaceutical Preparations: Application of Quantitative Chemical Analysis in Practice

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