Abstract: “Physical Chemistry One” is a core compulsory theoretical course for undergraduates majoring in chemistry in normal universities. Its curriculum innovation faces the needs of the cultivation of national innovative talents and the cultivation of high-quality middle school chemistry teachers in the new era. Guided by the threedimensional talent training objectives of “knowledge”, “ability” and “meaning”, under the “online and offline” integrated teaching and four innovative measures, the current difficulties and problems faced by the course are effectively solved. The students’ learning motivation is effectively stimulated, and their innovative consciousness and comprehensive quality are significantly improved. The present research provides a useful reference for the effective development of professional basic theory course teaching.

Key words: Double-line three-drive four-coupling, Physical chemistry, Curriculum innovation