Abstract: Chemical biology is one of the 12 core courses developed under the “101 Plan” for chemistry. As an emerging interdisciplinary field that explores the chemical basis and molecular foundations of life processes, chemical biology encompasses a broad range of topics and extensive knowledge. With ongoing advancements in the field, establishing a systematic curriculum that addresses the diverse needs of students from various disciplines presents a significant challenge for textbook design and construction. To address this, the authors have investigated and compared the content and curriculum design of different chemical biology textbooks, summarized the key modules and knowledge areas, and developed a teaching framework based on three main aspects: the molecular basis of chemical biology, core technologies, and applications. The textbook aims to showcase innovative features in knowledge integration, content depth, and practical orientation. By aligning with the development of interdisciplinary subjects and national strategic needs, the textbook seeks to provide a cross-disciplinary integration of chemistry, biology, and medicine, offering students a challenging and insightful learning experience.

Key words: Chemistry “101 Plan”, Chemical biology, Textbook design and construction