Abstract: Large-scale instrumental experiment courses serve as a crucial bridge linking theoretical knowledge with practical skills in undergraduate chemistry education. However, due to the complexity of instrument structures and the interdisciplinary nature of the required knowledge, traditional teaching approaches often struggle to engage students effectively. Guided by the educational philosophy of “contextualizing instrumentation, empowering learning”, this study proposes a student-centered blended teaching model that integrates virtual and physical realities. Specifically, immersive virtual reality (VR) technology is combined with actual instrument components, enabling students to visually and interactively understand instrument structures and operating principles. Additionally, role-playing activities from a scientist's perspective immerse students in historical contexts related to instrument invention and application. Furthermore, project-based teaching linked to authentic research tasks facilitates students' development of scientific thinking and comprehensive practical skills through addressing real-world challenges. Classroom implementation has demonstrated that this multifaceted educational model significantly enhances students' engagement, motivation, and active participation, offering an effective pathway for cultivating interdisciplinary competencies and practical abilities in future chemistry professionals.

Key words: Large-scale instrumental experiment, Virtual reality technology, Role-playing teaching, Ideological and political education, Project-based teaching