Abstract: In the face of intensifying global competition in science and technology, education plays a crucial role in cultivating innovative talents. Structural chemistry, a core foundational course for chemistry majors, employs quantum mechanics and group theory as its scientific language, enabling a deeper understanding of chemical principles and phenomena. This paper summarizes the reforms undertaken in the structural chemistry curriculum and textbook development under the Chemistry “101 Plan” and explores the pathways for reform in line with first-class curriculum standards. By restructuring the course’s knowledge modules, building a comprehensive knowledge framework, and introducing diversified teaching resources, these efforts have enhanced the quality of higher education and advanced the development of the chemistry discipline.

Key words: Chemistry “101 Plan”, Structural chemistry, Cultivation of top-notch innovative talent, Curriculum reform, First-class course