Abstract: With the trend of “Internet plus” and the reform of college entrance examinations, the teaching reform in the field of chemistry continues to deepen. The teaching team of the Structural Chemistry course at South China Normal University has conducted in-depth exploration and practice of blended teaching, combining online and offline methods. This article introduces the exploration, process, and implementation of the curriculum reform. By utilizing the “LiRu Online Courses” platform, the team has successfully integrated offline and online courses, leveraging their respective advantages to create an effective blended learning experience. The results of offline course exams, online participation rates, and student feedback all indicate that this blended teaching approach has been well received by students, leading to a significant improvement in their innovative thinking and achieving satisfactory teaching outcomes.

Key words: Structural chemistry, Online and offline blended teaching, LiRu Online Courses