Abstract: In the martial world, the notorious “Drug Sect” spreads chaos through their nefarious arts of addiction, hallucination, and narcosis, dragging countless victims into the abyss of substance dependence. To eradicate this threat and restore righteousness, an Anti-drug Crusader Squad has risen to wage war against the Drug Sect. Leveraging chemical and biological expertise, the crusaders have deciphered addiction mechanisms to develop long-acting opioid therapies against heroin and other opioids. Employing enzyme transition-state theory, they engineered catalytic antibodies for cocaine hydrolysis. Furthermore, they developed a cocaine vaccine by harnessing the immune system. While achieving significant victories against the Drug Sect, the crusaders remain vigilant as new synthetic drugs continue to emerge.

Key words: Drugs, Long-acting opioid therapy, Catalytic antibody, Vaccine, Addiction