研教融合型药学专业教学案例库的构建：以抗SARS-CoV-2药物研发为例

doi:10.3866/PKU.DXHX202308077

Abstract

Abstract:

The integration of research and teaching in pharmaceutical education provides valuable teaching materials for cultivating innovative pharmaceutical talents. The development of drugs against COVID-19 represents a concentrated embodiment of new strategies and technologies in the field of pharmacy, reflecting the high-level intelligence of pharmaceutical researchers. This article takes the development of anti-SARS-CoV-2 drugs as an example to explore and summarize the methods of constructing an integrated teaching case library for pharmaceutical education.

Key words: Case teaching, Antiviral drugs, SARS-CoV-2, Pharmacy major, Teaching method

Peng Zhan, Xinyong Liu. Construction of an Integrated Teaching Case Library for Pharmaceutical Education: A Case Study on the Development of Anti-SARS-Cov-2 Drugs[J].University Chemistry, 2023, 38(12): 10-17.

Figures/Tables 6

References 56

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药学课程	知识点	相关案例
无机化学	配位化学	具有抗SARS-CoV-2活性的配合物：铼配合物、锌配合物、铋配合物、金配合物
	生物无机化学	抗SARS-CoV-2新靶标：RNA依赖的RNA聚合酶中的Fe-S辅助因子
	生物无机化学	抗SARS-CoV-2新靶标：金属依赖性蛋白
	超分子化学	靶向SARS-CoV-2 RNA的超分子配位化合物
有机化学	核酸	核苷类SARS-CoV-2聚合酶抑制剂：阿兹夫定
生物化学	酶抑制剂类型与活性测试方法	SARS-CoV-2 3CL蛋白酶抑制剂作用机理与活性测试方法
分子生物学	mRNA	mRNA疫苗
	聚合酶链式反应	逆转录实时荧光定量PCR反应(RT-qPCR)
	聚合酶链式反应	DNA-encoded chemistry technology DNA编码库
免疫学	抗体、抗原基本概念	抗原检测技术、抗体检测技术、抗原抗体快速检测技术等
药物化学	共价结合	奈玛特韦
	前药	瑞德西韦
	拟肽	奈玛特韦
	虚拟筛选	恩司特韦(Ensitrelvir)
	老药新用	瑞德西韦、阿兹夫定

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Construction of an Integrated Teaching Case Library for Pharmaceutical Education: A Case Study on the Development of Anti-SARS-Cov-2 Drugs

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