Abstract: Electrochemical organic synthesis is an environmentally friendly, mild, and efficient methodology that has gained widespread acceptance in oxidation, reduction, and redox reaction systems, showcasing significant potential. This experiment focused on the synthesis of selenium-containing pyranones and chalcones using 1-(2-methoxyphenyl)-3-phenylpropyl-2-oxo-1-one and diphenyl diselenide (PhSeSePh) as starting materials, employing a solvent controlled electrochemical strategy to construct C―Se bonds and explore innovative electrochemical synthesis methods for selenium-containing compounds. Drawing on the research achievements of our group, we have designed a comprehensive experiment for the solvent-regulated electrochemical synthesis of these compounds. The experimental framework involves various operational steps, such as substrate preparation, electrochemical synthesis analysis, cyclic voltammetry studies, structural characterization of target products, and crystal cultivation. This hands-on approach enhances students’ practical skills in experimental techniques, silica gel column chromatography separation and purification, and structural analysis. Our experimental design emphasizes green organic synthesis, integrating interdisciplinary knowledge from both organic chemistry and electrochemistry to develop novel synthetic methods for selenium-containing heterocyclic compounds.

Key words: Electrochemical synthesis, Pyranone, Chalcone, Organic selenides, Comprehensive experiment