Abstract: The copper/dioxygen catalyzed radical reactions that features high reaction efficiency, mild reaction conditions, good functional group compatibility and environmental friendliness, has been widely applied in organic synthesis. Inspired by the principles of green and sustainable development and drawing on our recent research findings, we designed a comprehensive experiment for the copper/dioxygen-catalyzed cleavage of C―C bonds in amides to synthesize asymmetric urea derivatives at room temperature. This experiment features readily accessible starting materials, mild reaction conditions, ease of execution, and does not require complex instrumentation. It effectively fosters students’ innovative abilities while providing insights into the forefront of radical chemistry. Consequently, this experiment holds significant practical and educational value.

Key words: Copper catalysis, C―C bond cleavage of amides, Urea derivatives, Organic chemistry laboratory